An international tribunal Thursday indicted the Bosnian Serbs' top two leaders for more war crimes, charging them with genocide in the Muslim enclave of Srebrenica.

Bosnian Serb leader Radovan Karadzic and army commander Gen. Ratko Mladic are already charged with war crimes against Bosnia's Muslims and Croats, including attacks on Sarajevo.The new indictments come just days after newspapers reported that Mladic and Karadzic agreed to relinquish power once a U.S.-sponsored peace deal is signed in exchange for not being handed over to the war crimes tribunal.

The indictment charges Karadzic and Mladic with crimes against humanity and genocide, describing them as the architects of perhaps the worst massacre in Europe since World War II.

Karadzic and Mladic are accused of ordering atrocities committed in July 1995 against the Bosnian Muslim population of the U.N.-designated safe area of Srebrenica. The tribunal called the massacre one of cruelest and bloodiest acts of the war in the former Yugoslavia.

The latest indictments against the two appeared certain to further isolate the Bosnian Serb leadership at a time where the leaders of Serbia, Bosnia and Croatia are trying to hammer out a U.S.-brokered peace accord.

The charges will have no immediate effect on peace talks near Dayton, Ohio, which Karadzic and Mladic were barred from attending because of the earlier indictments. Serbian President Slobodan Milosevic is negotiating on behalf of Bosnia's Serbs.

But the new indictments stand as a fresh reminder to Milosevic of international pressure to dump Karadzic and Mladic as leaders, ensuring they don't have key roles in any future Bosnian state.

The United States has said it would not send troops to monitor a peace agreement as long as the two remained in power.

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After the fall of Srebrenica to Bosnian Serb forces, an estimated 25,000 Muslim refugees fled to the nearby town of Potocari, headquarters of Dutch peacekeepers.

But the Serbs deported thousands of Muslims to Bosnian government lines after reportedly separating out men and boys.

About 8,000 refugees have been missing ever since, according to the international Red Cross, and Western governments have said evidence, including satellite photos of alleged mass graves, suggests mass executions.

Tribunal documents give a grisly description of the massacre of Muslims after the fall of Srebrenica: "Thousands of men executed and buried in mass graves, hundreds of men buried alive, men and women mutilated and slaughtered, children killed before their mothers' eyes, a grandfather forced to eat the liver of his own grandson."

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