MEMPHIS, Tenn — Michigan State had too much in too many ways for Fresno State and the defending national champion is in the round of 16 for the fourth straight year.
The top-seeded Spartans (26-4) had eight players score six or more points in an 81-65 victory over No. 9 Fresno State on Sunday and they advanced to regional semifinals.
They will play 12th-seeded Gonzaga, which beat No. 13 Indiana State 85-68 in the second round, on Friday in Atlanta.
The four straight appearances ties Duke, the top seed in the East, for the longest current streak.
The Spartans held the Bulldogs (26-7) 17 points below their average for the season and, as expected, dominated the rebounding. Michigan State, which led the nation for the second straight year in rebound margin at plus-15.5, outrebounded the Bulldogs 48-32. Fresno State was last in the Western Athletic Conference in that statistic at plus-1.6.
Charlie Bell and Aloysius Anagonye each had 13 points to lead the Spartans, who are looking for their third straight Final Four appearance. Andre Hutson added 12 points and eight rebounds for Michigan State, while David Thomas had 10 points and 14 rebounds.
Melvin Ely, the WAC player of the year, led the Bulldogs with 17 points, but they came in 27 minutes as he fought foul trouble throughout and played the final 16:58 with four fouls.
The loss ended coach Jerry Tarkanian's pursuit of a 14th trip to the round of 16 in 18 tournaments. The Bulldogs' win over California in the first round was his first NCAA win at Fresno State and first since he led UNLV to the Final Four in 1991. His other round of 16 appearances came at Long Beach State (4) and UNLV (9), where he won the national championship in 1990.
A drive by Mike Chappell gave Michigan State its biggest lead of the first half, 34-20 with 4:49 left, and the Spartans led 37-20 at halftime, holding the Bulldogs to 29 percent shooting, including 0-for-9 from 3-point range.
GONZAGA 85, INDIANA STATE 68: At Memphis, Tenn., No upset necessary for Gonzaga this time.
The Bulldogs finally got to play a lower seed in the NCAA tournament and now head to the round of 16 for the third straight year.
Casey Calvary scored 24 points and Dan Dickau added 20, making all 12 of his free throws, as 12th-seeded Gonzaga beat No. 13 Indiana State 85-68 Sunday at the South Regional.
The Bulldogs (26-6) will play either top-seeded Michigan State or No. 9 Fresno State in a regional semifinal in Atlanta on Friday.
Gonzaga came within one victory of the Final Four as a 10th seed in 1999, and reached the round of 16 from the same slot last year. Each time, the Bulldogs knocked out second-seeded teams in the second round.
On Sunday, though, Gonzaga had some trouble early against the Sycamores (22-12), whose first-round win over Oklahoma was their first tournament success since Larry Bird led the team to the 1979 championship game.
After Marcus Howard's 3-pointer put Indiana State up 51-48 with 12:09 left, Gonzaga coach Mark Few called a timeout and yelled "Settle down!" at his players.
That was all it took to get Gonzaga going.
Calvary and freshman Kyle Bankhead each hit 3-pointers, and Dickau made a smooth spinning move down the lane to put the Bulldogs ahead 56-51 with 9:17 remaining.
A barrage of 3-pointers from both sides followed, with Indiana State's Michael Menser hitting two 3s sandwiched around one by Calvary.
Matt Renn's 3-pointer for the Sycamores tied it at 60, but Dickau followed with a pull-up jumper and two free throws to put Gonzaga ahead 64-60 with 7:23 to go.
Then, after Menser hit yet another 3-pointer to pull Indiana State within 66-65 with 6:06 remaining, Zach Gourde's basket 20 seconds later started an 11-0 Gonzaga run that sealed the victory.
Gourde scored 15 points, and Alex Hernandez 12 for the Bulldogs, who beat Stanford in 1999 and then St. John's last year in the second round.
Renn and Howard each scored 16, and Menser added 15 for Indiana State.
Indiana State led 37-32 after a tight and fast-paced first half. But Dickau, who didn't have a field goal in the opening 20 minutes, had a rebound basket and made a free throw to start Gonzaga on a 9-0 run to go ahead 45-43 with 14:48 left.
Gonzaga looked like the inexperienced tournament team in the first half with sloppy plays, missed shots and 13 turnovers.
Dickau, who scored 21 points in the first half against Virginia in the first round, only scored on three free throws and had four turnovers. The Zags, who average 14.3 turnovers a game, had just two in the second half.