The top rushing performances in NFL history with yardage, player, number of attempts in parentheses, team, opponent, touchdowns and date:
295 — Jamal Lewis (30), Baltimore, vs. Cleveland, 2 TDs, Sept. 14, 2003.
278 — Corey Dillon (22), Cincinnati, vs. Denver, 2 TDs, Oct. 22, 2000.
275 — Walter Payton (40), Chicago, vs. Minnesota, 1 TD, Nov. 20, 1977.
273 — O.J. Simpson (29), Buffalo, vs. Detroit, 2 TDs, Nov. 25, 1976.
266 — Shaun Alexander (35), Seattle, vs. Oakland, 3 TDs, Nov. 11, 2001.
251 — Mike Anderson (37), Denver, vs. New Orleans, 4 TDs, Dec. 3, 2000.
250 — O.J. Simpson (29), Buffalo, vs. New England, 2 TDs, Sept. 16, 1973.
247 — Willie Ellison (26), Los Angeles, vs. New Orleans, 1 TD, Dec. 5, 1971.