Peyton Manning, Colts QB, completed 26 of 35 passes for 297 yards and three touchdowns as Indianapolis remained unbeaten on the year.
Joey Harrington, Lions, QB, was 22-of-32 for 231 yards with three TDs and no interceptions in a 29-21 victory over the Cardinals.
Gus Frerotte, Dolphins, QB, went 25-for-47 for 360 yards with two touchdowns and one interception in Miami's 23-16 loss to New England.
Roy Williams, Lions, WR, caught a career-high three touchdown passes to lead Detroit past Arizona 29-21. He had seven receptions for 117 yards.
Shaun Alexander, Seahawks, RB, rushed for 165 yards on a season-high 33 carries and three touchdowns, and the Seahawks beat the mistake-prone Rams 31-16.
Larry Johnson, Chiefs, RB, had 132 yards rushing in his first start since Priest Holmes was lost for the season, but Kansas City fell 14-3 at Buffalo.
Edgerrin James, Colts, RB, ran 26 times for 122 yards and one touchdown, his 47th career 100-yard game, as Indianapolis beat Houston 31-7.