HOUSTON — Greg Maddux outpitched Roger Clemens in a rare duel between 300-game winners, and Jeromy Burnitz hit a tiebreaking homer in the seventh inning to lead the Chicago Cubs over the reeling Houston Astros 3-2 Friday night.

Maddux (1-1) got his 306th career win and first since the Cubs' 2004 season-finale against Atlanta. He lasted six innings, giving up two runs on seven hits with three strikeouts and one walk.

Maddux was lifted in the seventh for a pinch-hitter, and Michael Wuertz, Will Ohman and Roberto Novoa combined to pitch two scoreless innings before LaTroy Hawkins pitched a scoreless ninth for his fourth save.

Clemens (1-1) pitched seven strong innings to hold up his end of the marquee matchup. The Rocket allowed three runs on seven hits and struck out five while walking two. He even went 2-for-2 at the plate, only the second multihit game of his 22-year career.

But mostly because of the Houston offense, second-worst in the majors, Clemens failed in his fourth straight attempt at winning his 330th game and remained tied with Steve Carlton for ninth on the all-time list.

Burnitz went 3-for-4, driving in two runs and finishing only a triple short of the cycle to decide the first matchup between 300-game winners in almost 18 years.

Before Friday, there had been only four matchups of 300-game winners in the modern era, all between June 28, 1986 to Aug. 4, 1987, all involving California's Don Sutton in the American League. Sutton made two starts against Phil Niekro and one apiece against Tom Seaver and Carlton.

The last time two NL pitchers with 300 or more victories faced each other was in July 21, 1892, between Philadelphia's Tim O'Keefe and St. Louis' Jim "Pud" Galvin.

This could be the last matchup between 300-game winners for a long time. Tom Glavine of the New York Mets is the closest active pitcher to 300 wins with 263, and he's 39-years-old.

Not surprisingly, offense was in short supply with Clemens and Maddux bringing a combined 11 Cy Young Awards — seven for Clemens and four for Maddux — into their highly anticipated duel.

Coming off an 0-5 trip that ended with consecutive 2-0 losses at Pittsburgh, the Astros did all of their scoring early.

Mike Lamb, filling in for struggling rookie outfielder Luke Scott, ended the Astros' streak of scoreless innings at 21 with an RBI double in the first.

The Cubs responded by snapping Clemens' streak of 24 consecutive scoreless innings on Burnitz's bloop RBI single in the second. Hollandsworth followed with a run-scoring double to give Chicago a 2-1 lead.

Houston's Jeff Bagwell led off the fourth with a 347-foot shot that landed just inside the left foul pole, tying the game at 2-all. It was Bagwell's seventh career homer off Maddux.

But Burnitz sent Clemens' pitch 407 feet over the right-field fence in the seventh — only the second homer Clemens has allowed this year — for the go-ahead score.