WASHINGTON — Health officials said Monday they have ruled out the abortion pill RU-486 in one of two deaths in women who had taken the drug. The second remains under investigation.
The one death was unrelated to either abortion or use of the pill, the Food and Drug Administration said. The second woman showed symptoms of infection. Four other women have died of a rare but deadly infection after undergoing pill-triggered abortions.
In those four deaths, all involving Californians, the women tested positive for Clostridium sordellii, a common but rarely fatal bacterium.
The FDA has warned doctors to watch for infection by the bug. However, the drug, also called Mifeprex or mifepristone, has not been proved to be the cause in any of those cases, the FDA has said.
The recent deaths sparked renewed calls to ban the abortion pill.
Republican Sens. Jim DeMint of South Carolina and Tom Coburn of Oklahoma, urged passage of legislation that would suspend sales of RU-486 after the latest deaths were made public in March. The two legislators want the Government Accountability Office to review how the FDA approved the pill.
The FDA approved RU-486 in 2000 for use in ending a pregnancy up to 49 days after the beginning of the latest menstrual cycle.
Neither of the two women followed FDA-approved instructions for the pill, which require swallowing three tablets of one drug, followed by two of another two days later.
Instead of swallowing the final two tablets, the second course of pills was inserted vaginally in the four women, an "off-label" use that studies have shown effective and that has been recommended by a majority of the nation's abortion clinics. That use does not have federal approval though studies have indicated it produces fewer side effects.
Planned Parenthood Federation of America Inc. said it would immediately stop recommending vaginal insertion of the final course of pills. Four of the women who died, including the latest two, received the pills at Planned Parenthood-affiliated clinics. Planned Parenthood estimates RU-486 has been used 560,000 times in the U.S. since it was approved.
RU-486 is sold by Danco Laboratories. It works by blocking a hormone required to sustain a pregnancy. When followed two days later by another medicine, misoprostol, to induce contractions, the pregnancy is terminated.
Federal health officials plan a May 11 workshop in Atlanta to discuss emerging cases of disease involving C. sordellii, which also have included infections in patients who have received skin grafts.
FDA said it has tested batches of the abortion pill but has not found any contamination by the bacteria.
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Food and Drug Administration: www.fda.gov