LOS ANGELES — Michael Jackson's death was a homicide caused primarily by the powerful anesthetic propofol and another sedative, the coroner announced Friday in a highly anticipated ruling increasing the likelihood of criminal charges against the pop star's doctor.

The Los Angeles County coroner's office determined the cause of death was "acute propofol intoxication." Lorazepam, another sedative sold under the brand name Ativan, contributed to the death.

Additional drugs detected in Jackson's system were the sedatives midazolam and diazepam, the painkiller lidocaine and the stimulant ephedrine.

The coroner did not release Jackson's full autopsy report, citing a security hold requested by Los Angeles authorities investigating the case, and declined to comment beyond a short statement announcing the manner and cause of death.

The coroner's determination of a homicide confirmed what The Associated Press first reported Monday, citing an anonymous law enforcement official.

The 50-year-old Jackson died June 25 at his rented Los Angeles mansion. Dr. Conrad Murray, the Las Vegas cardiologist who was the pop star's personal physician, told police he gave Jackson propofol that morning after a series of sedatives failed to help Jackson sleep.

Murray has not been charged with any crime but is the target of what police term a manslaughter investigation. Multiple search warrants served at his home and businesses in Las Vegas and Houston sought evidence detailing how he procured the propofol that killed Jackson. Jackson's interactions with at least six other doctors also are being scrutinized.

In addition, California Attorney General Jerry Brown has opened an independent probe of several physicians.

Except for a brief video posted to YouTube earlier this month, Murray has not spoken publicly since Jackson's death. In the video, he said: "I told the truth and I have faith the truth will prevail."