Pittsburgh's 60-50 victory over Villanova on Saturday gave the Panthers the outright Big East regular-season title and set the first five seeds for next week's conference tournament.
Pittsburgh (15-3) will be the No. 1 seed and along with Notre Dame, Louisville and Syracuse will receive a double-bye into Thursday's quarterfinals.
No. 5 St. John's was the only seed set through Saturday's afternoon games and will get a bye to Wednesday's second round.
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The remaining positions were to be decided by Saturday night's games.