Although epidemiologists have not yet identified the person who brought measles to Disneyland, a new analysis shows that the highly contagious disease has spread to seven states and two other countries thanks to parents who declined to vaccinate their children.
Using some simple math, a team of infectious disease experts calculated that the vaccination rate among people who were exposed to the measles during the outbreak was no higher than 86 percent, and it might have been as low as 50 percent.
In order to establish herd immunity, between 96 percent and 99 percent of the population must be vaccinated, experts say.
“Even the highest estimated vaccination rates from our model fall well below this threshold,” the researchers reported Monday in the journal JAMA Pediatrics.
The analysis underscores that, in preventing outbreaks, “it’s not just about policy but about compliance,” said Erez Hatna, an infectious disease modeler at Johns Hopkins University Medical School, who wasn’t involved in the study.
If vaccination rates continue to fall so far below the levels required for herd immunity, more outbreaks should be expected in places where the unvaccinated mix and in their communities when they return home, Hatna added.
The research team, from the Massachusetts Institute of Technology and Boston Children’s Hospital, calculated the range of likely vaccination rates based on a few key data points. Based on historical data, infectious disease experts know that in the absence of any vaccination, a single person infected with measles can spread it to between 11 and 18 other people. They also know that it takes 10 to 14 days for one measles case to lead to another.
The last variable in their equation is the number of people in a semi-vaccinated community who actually become infected after exposure to a single person with measles. Since this figure — called the effective reproductive number — isn’t precisely known, the researchers considered scenarios where it was as low as 3.2 and as high as 5.8.
In the best-case scenario, the vaccination rate among people who encountered the measles as a result of the Disneyland outbreak was between 75 percent and 86 percent, the researchers calculated. If the true effective reproductive number was in the middle of the range, the vaccination rate would have been between 66 percent and 81 percent. If the effective reproductive number was high, the vaccination rate had to have been between 50 percent and 71 percent, according to the study.
In other words, the only way to explain how the measles spread from a single person at Disneyland to 145 people in the U.S. and about a dozen others in Canada and Mexico is that a substantial number of parents have not had their children fully immunized with the measles, mumps and rubella vaccine.
“Clearly, MMR vaccination rates in many of the communities that have been affected by this outbreak fall well below the necessary threshold to sustain herd immunity, thus placing the greater population at risk as well,” the researchers concluded.
Measles is a highly infectious viral disease that remains a leading cause of death in children worldwide. After patients cough or sneeze, the virus particles can survive as long as two hours on doorknobs, hand rails, elevator buttons and even in the air.
Despite the fact that a vaccine has been available for decades, about 400 people died from measles every day in 2013, according to the World Health Organization. Before vaccination became widespread, the disease killed about 2.6 million people per year, the WHO says.
The index patient in the 3-month-old Disneyland outbreak was probably exposed to the measles overseas and then visited the Anaheim, Calif., amusement park while contagious, according to the Centers for Disease Control and Prevention. This particular strain of measles is “identical” to one that spread through the Philippines last year, where it sickened about 58,000 people and killed 110.
No deaths have been traced to the Disneyland outbreak.
In Orange County, where Disneyland is located, the outbreak has sickened 35 people, including 14 children. Two of those children were too young to be vaccinated, and another had received only one of the two doses that are recommended, according to the Orange County Health Care Agency.
“This underscores the importance of vaccination in preventing the spread of measles, and protecting children who are too young to be vaccinated,” said Dr. Eric Handler, Orange County’s public health officer.
Public health officials do keep track of vaccination rates. In California, for instance, the state Department of Public Health reported that 92.6 percent of kindergarten students had received at least two doses of the MMR vaccine in the 2014-15 school year.
So why did the study authors go to all this trouble? In an outbreak involving a major tourist destination such as Disneyland, there is no single state, county or school district that can report the overall vaccination rate, the researchers wrote. As a result, mathematical modeling like this may give a clearer picture than any individual government agency.
The scope of the multi-state outbreak is certainly a reflection of the anti-vaccination movement, which continues to grow despite overwhelming medical evidence that the MMR vaccine does not cause autism or other developmental problems. In most cases, side effects are limited to pain at the injection site, fever, a mild rash or temporary swelling, according to the CDC. In rare cases, children may have a severe allergic reaction to the vaccine or develop febrile seizures, joint pain, temporary arthritis or a blood disorder called immune thrombocytopenic purpura.
The outbreak “shines a glaring spotlight on our nation’s growing anti-vaccination movement and the prevalence of vaccination-hesitant parents,” the authors wrote.
In California, three state legislators have introduced a bill that would make it more difficult for parents to opt out of vaccinations by claiming a personal belief exemption. The bill, SB 277, would require children to be vaccinated against measles and other infectious diseases before enrolling in California schools.
One of the sponsors of the bill is Dr. Richard Pan, a pediatrician who represents Sacramento.
(Times staff writers Melissa Healy in Bethesda, Md., and Rong-Gong Lin II in Los Angeles contributed to this report.)
©2015 Los Angeles Times
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