Frederic de Hoffmann, former president of the Salk Institute and a well-known nuclear physicist who worked on the Manhattan Project, died Wednesday of complications from AIDS. He was 65.

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A native of Vienna, Austria, de Hoffmann went to Los Alamos, N.M., in 1944, to work on the Manhattan Project, which developed the atomic bomb.In 1955, de Hoffmann encouraged General Dynamics Corp. to establish a new division, General Atomics, to manufacture nuclear reactors and sell them on the open market for use as energy producers.

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