Diagnosis Murder (7 p.m., Ch. 2): Two comics are killed at a celebrity roast, which features Steve Allen, Ruth Buzzi, Tim Conway, Norm Crosby, Julia Duffy, Dick Martin, Jayne Meadows and Tom Poston. (Season premiere)
Whose Line Is It Anyway? (7 and 7:30 p.m., Ch. 4): Drew Carey hosts this improvisational comedy show.
Friends (7 p.m., Ch. 5): TV's funniest comedy returns with a very good episode in which Monica and Chandler make a decision about their future, and Ross and Rachel don't. (Season premiere)
Jesse (7:30 p.m., Ch. 5): NBC performs some major surgery in an attempt to save this quality-challenged sitcom. Former BYU student Kevin Rahm joins the cast as a possible new love interest for Jesse. (Season premiere)
Chicago Hope (8 p.m., Ch. 2): David E. Kelley wrote this episode, which bodes well for the show's future. Mandy Patinkin returns and Lauren Holly, Barbara Hershey and Carla Gugino join the cast. (Season premiere)
Frasier (8 p.m., Ch. 5): Frasier doesn't realize that the woman he's fallen for bears a stunning resemblance to his late mother. (Season premiere)
Live from Lincoln Center (8 p.m., Ch. 7): The New York Philharmonic opens the 1999-2000 season.
Stark Raving Mad (8:30 p.m., Ch. 5): Disappointing new sitcom.
48 Hours (9 p.m., Ch. 2): A report on a slick con-man.
Third Watch (9 p.m., Ch. 5): This frantically paced new show about cops, firefighters and paramedics is from the producers of "ER," which explains the similarities. Be aware that it's also violent and replete with sexual dialogue.