Pedro Feliz's struggles batting behind Barry Bonds earlier this series forced manager Felipe Alou to move him around in the order.
On a day Bonds sat out of the lineup, Feliz found his stroke.
Feliz homered twice and Yorvit Torrealba hit a three-run homer that staked San Francisco to a five-run lead in the first inning of the Giants' 10-5 win over the Colorado Rockies on Monday in Denver.
Pinch-hitter Damon Minor singled home the tiebreaking run in the seventh inning. The Giants won three of four and sent Colorado to its fifth series loss at Coors Field this season.
Feliz hit a solo homer in the eighth and a two-run homer in the ninth for his 10th and 11th homers of the year. He had his third career multihomer game and second this season.
"I made an adjustment," said Feliz, who went 0-for-5 and stranded eight runners hitting behind Bonds in Saturday's 11-2 loss. "I was trying to do too much. I was more patient the last few at-bats."
It was Denver's hottest June 7 ever — breaking a 130-year-old record. The temperature at first pitch was 93 degrees and it quickly climbed to 98.
That was one of the reasons Bonds didn't start for the Giants, though he did draw an intentional walk as a pinch-hitter in the seventh. He played the first three games of the series in left field , including Sunday's day game that followed a night game, something he rarely did last year .
The six-time NL MVP has 674 career homers and 16 this season heading into interleague play. The Giants conclude their season-long 14-game road trip with three games each at Tampa Bay and Baltimore.
"The toughest part is over. I'm not talking team wise, I'm talking four-game series," Alou said, referring also to a four-game set at Arizona that kicked off the trip. "It's very tough to play four games in the same place. Nobody likes four-game sets."
Alou was happy to hear Devil Rays manager Lou Piniella plans to pitch to Bonds — unless it's "a game-winning situation in the late innings," Piniella said.
Bonds will be the designated hitter in the upcoming games, but there's a chance he will return to the Bay area later this week for a day to attend the funeral of the mother of one of his closest childhood friends. He said after the game he didn't know what his schedule will be, but he was headed out on the team charter to Florida.
Jim Brower (3-3) pitched the sixth as four relievers combined for four hitless innings. San Francisco beat the Rockies for the sixth time in seven games this year.
"It was a tough series in Arizona," Brower said of the Giants' three losses. "The hitters came up huge today. We struggled as a bullpen until today."
Minor, batting for Cody Ransom, singled with two outs off Steve Reed (0-1).
Colorado's Jeromy Burnitz hit a tying, two-run homer in the third to make it 5-all, his 16th this season.
Shawn Estes got his third straight no-decision for the Rockies, while Giants starter Brett Tomko remained winless in seven starts. Both pitchers allowed five runs.
"This is a crazy ballpark," Tomko said. "I've seen a whole bunch of guys give up eight runs and the team still wins."
Aaron Miles doubled twice and singled for the Rockies, who open interleague play Tuesday with their first appearance at Yankee Stadium.
Estes plunked Michael Tucker with the first pitch of the game. A day earlier, Reed was ejected in the eighth inning for arguing a hit batter call.
On Sunday, A.J. Pierzynski leaned his right elbow into a pitch with the bases loaded. Reed argued that Pierzynski didn't try to get out of the way. Manager Clint Hurdle had to restrain Reed, who said plate umpire Bruce Dreckman swore at him repeatedly and then immediately tossed the pitcher.
On Monday, both Hurdle and Alou came out to speak to the same umpire crew after Estes hit Tucker. Both benches were warned, then Tomko knocked down Todd Helton in the third and Brower later plunked Kit Pellow.
"It doesn't do any good to talk to the umpires," Hurdle said. "They aren't going to change anything. Nothing happened."
CARDINALS 4, CUBS 3: At Chicago, Scott Rolen made up for the absence of injured Albert Pujols with a three-run homer, and Chris Carpenter (7-1) tied his career-best with his sixth straight win, giving up three runs and nine hits in 8 1-3 innings.
Reggie Sanders also homered for the Cardinals, who have won 10 of 12. Jason Isringhausen got the final out for his 13th save.
Corey Patterson and Glendon Rusch (2-1) homered for the Cubs. Rusch gave up four runs and six hits in seven innings as Chicago lost for the ninth time in 13 games.
INTERLEAGUE
RANGERS 6, PIRATES 5: Hank Blalock hit an RBI single with two outs in the 10th inning as Texas defeated Pittsburgh in the first interleague game of the season.
Blalock's looper to center, on a full-count pitch from Mike Johnston (0-3), dropped in front of charging outfielder Tike Redman to score Laynce Nix.
Francisco Cordero (2-0) pitched two scoreless innings.
Pittsburgh, with manager Lloyd McClendon back after a two-game suspension, lost for the eighth time in nine games and dropped to 0-4 against Texas.
ATHLETICS 13, REDS 2: At Oakland, Calif., Mark Mulder stalled Ken Griffey Jr.'s run for 500 homers on a night when the Athletics delivered most of the longballs, getting a grand slam from Scott Hatteberg in a 13-2 win.
Griffey singled and scored in the second and grounded out twice before being replaced in the sixth inning trailing 11-2. He'll try again Tuesday night against Barry Zito.
Mark Kotsay, Erubiel Durazo and Damian Miller also homered for the A's, who have won six of seven to move a season-high eight games over .500.
MARINERS 5, ASTROS 0: At Seattle, Clint Nageotte pitched six shutout innings in his first major league start, leading Seattle to a 5-0 win over Houston.
Nageotte (1-1) was a top Mariners prospect last year after leading the Double-A Texas League with 157 strikeouts. He was solid all night, allowing six hits with eight strikeouts and three walks.
Scott Spiezio had a solo homer, two singles and two RBIs as the Mariners scored three runs off starter Brandon Duckworth (1-1) in only one-third of an inning, the shortest outing of his career.