Brigham Young and those who crossed Iowa with him in 1846 crossed and camped near the Chariton River during March 22-31, 1846. The site is in Appanoose County between the towns of Exline and Moulton.
This river crossing was very challenging because of the inclement weather that turned the steep banks on either side of the river into slippery hills of deep mud. Moreover, the river, which was normally 2 feet deep, was rising because of all the rain. The company spent most of March 22 crossing over but camped for several more days because of the weather and miserable trail conditions.
Zina Huntington Jacobs, who was later the third general president of the Relief Society of The Church of Jesus Christ of Latter-day Saints, delivered a baby boy on the 22nd and named him Henry Chariton Jacobs.
Incidentally, the Chariton River runs by Sharon Bluffs State Park in Iowa. In response to the question of where the name Sharon Bluffs came from, a park ranger said it was named by Mormons because it reminded some of them of Sharon, Vermont, where Joseph Smith was born.