A crowded express train slammed head-on into a freight train north of Karachi early Saturday, killing at least 100 people and injuring scores more, railway officials said.

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The death toll was expected to rise as rescue workers cut through the twisted wreckage in what is believed to be Pakistan's second worst train accident, the officials said.The express, which travels the Karachi-Lahore-Islamabad route, was headed north for Lahore at about 40 miles an hour when it slammed into the freight train parked at the station in Ghotki, 400 miles north of Karachi in Sindh province. Dozens of train cars derailed, officials said.

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