Dr. Anthony Fauci spoke with actor Matthew McConaughey Thursday night about the novel coronavirus and the federal government’s response to the pandemic. Though he pledged support for a national mask mandate, he also pointed out a major issue with mandates.

What’s happening:

Fauci told McConaughey that “everybody should have to use” a mask to fight the coronavirus pandemic. But should there be a mask mandate for the entire country?

Here’s what Fauci said:

“You make a really good point that is the subject of a lot of debate. My recommendation, as you probably know because I’ve said it publicly so many times, is that absolutely we should have universal wearing of masks.”

“The difficulty with mandates is that it tends to be a pushback about, ‘Do you have to waste time enforcing it, or can you really use the power of persuasion from the leadership, everybody doing it, because it’s so important?’ And there’s a debate whether you get any extra mileage out of mandating it. Myself, personally, I would say everybody should have to use it.”

Fauci said a vaccine will help defend the country against the virus more than antibodies will, according to Fox News.

Joe Biden calls for mandate

Former Vice President Joe Biden and his running mate, Sen. Kamala Harris, D-Calif., called for a national mandate to help put a Band-Aid on the pandemic bullet wound, CNBC reports.

“Every single American should be wearing a mask when they’re outside for the next three months at a minimum. Every governor should mandate mandatory mask wearing. The estimates by the experts are that it will save over 40,000 lives in the next three months. Forty thousand lives, if people act responsibly.”

Trump responds to Biden

President Donald Trump responded to Biden’s call for a mandate during a press conference on Thursday.

“At every turn, Biden has been wrong about the virus, ignoring the scientific evidence and putting left-wing politics before facts. Sleepy Joe opposed both the China and Europe travel bans. He opposed the China travel ban that I instituted very early and the Europe ban I instituted quite early.”