PARIS -- Seventh-seeded Nathalie Tauziat bowed out of her 17th French Open on Friday, losing to American Chanda Rubin 6-4, 7-6 (3).
Another seeded Frenchwoman, No. 10 Sandrine Testud, also was eliminated. Asa Carlsson rallied to beat Testud 4-6, 6-3, 7-5.The upsets left 10 of the 16 seeded players in the women's draw, including three from France. The last Frenchwoman to win the French Open was Francoise Durr in 1967.
In men's play, No. 10 Alex Corretja beat Richard Krajicek 4-6, 6-2, 6-3, 6-2. Twelve seeded players remained in the men's draw.
On the warmest day of the tournament, with temperatures in the 80s, Rubin reached the fourth round at Roland Garros for the third time. She's best remembered in Paris for rallying from a 5-0, 40-love deficit in the third set to beat Jana Novotna in 1995.
Tauziat, 32, struggled with her serve and played a shaky tiebreaker, netting an easy volley and then hitting a lob long on match point. She has never had much success in the French Open, reaching the quarterfinals only once.
Tauziat's 17 appearances at Roland Garros ties a record. She plans to retire at the end of this year.
Carlsson, ranked 53rd, needed nearly 2 1/2 hours to beat Testud. The Swede reached match point by hitting a lunging volley for a winner, and when Testud dumped her final shot into the net, Carlsson let out a yelp and jumped up and down with glee.
Lindsay Davenport, bothered by back spasms in a first-round upset loss to Dominique Van Roost, pulled out of doubles because of the injury.
The only U.S. player still standing in the men's draw was a familiar name, but surprising nonetheless: Michael Chang.
Top-seeded Andre Agassi, No. 2 Pete Sampras and six unseeded Americans lost in the first two rounds. Agassi, the defending champion, developed blisters on his big toe Thursday and was eliminated by Karol Kucera 2-6, 7-5, 6-1, 6-0.
Chang, the 1989 champion, was scheduled to play fifth-seeded Gustavo Kuerten on Friday. It's the first time the injury-plagued Chang has reached the third round at a Grand Slam in two years.
Sampras' loss Monday was barely an upset, because he usually struggles on clay. But Agassi's defeat registered as a shocker, particularly because he lost 16 of the final 17 games.
He was so disappointed that he left for home in Las Vegas without talking to reporters. He rode back to his hotel with girlfriend Steffi Graf, coach Brad Gilbert and trainer Gil Reyes.
"No one said anything," Reyes said. "We want to give him some space right now. He's feeling an enormous amount of disappointment.
"It's very unfortunate, something completely unforeseen. He trained for this tournament as hard as he ever has for any tournament. It meant a lot to him, and he really wanted to win."
Moments after Agassi's defeat, No. 3 Magnus Norman completed a 6-1, 6-4, 6-2 win over Fabrice Santoro. Norman is the top remaining men's seed.
"I'm playing the best tennis of my life," he said.
No. 6 Cedric Pioline, No. 7 Thomas Enqvist and No. 9 Lleyton Hewitt also won Thursday.
Agassi appeared on the verge of an easy victory, leading 5-3 in the second set, before blisters on the big toe of his right foot began to bother him. He requested a trainer and received treatment at 4-1 in the third set.
The blisters tore open and Agassi couldn't move, even after he had the toe taped, Gilbert said.
The loss ends his run of four consecutive Grand Slam finals, a feat last achieved by Rod Laver in 1969. Agassi was trying to become the first man to win consecutive French Open titles since Sergi Bruguera in 1993-94.